Anua PDRN Hyaluronic Acid 100 Cream
Links may contain affiliate codes.
Formulation Summary
A hydrating cream combining Sodium DNA (the cosmetic form of PDRN) with eight molecular weight variants of hyaluronic acid. The formula supports barrier repair with ceramide NP, squalane, and panthenol. Designed as a deep hydration cream that addresses multiple layers of skin moisture retention.
Anua builds this cream around the PDRN trend in K-beauty, using Sodium DNA as the cosmetic-grade version. The formula pairs this with eight distinct hyaluronic acid types at different molecular weights to target hydration at multiple skin depths. Ceramide NP and squalane provide lipid barrier support. The formula avoids fragrance and essential oils. Dimethicone provides occlusion to help seal in moisture.
Quick Facts
Designed For
- •Those seeking intense multi-layer hydration
- •Users curious about PDRN skin repair benefits in a moisturizer
- •Sensitive skin types needing a fragrance-free hydrating cream
- •People with dehydrated skin looking for barrier support
- •K-beauty enthusiasts interested in the PDRN ingredient trend
May Not Suit
- •Users sensitive to fatty alcohols (cetearyl alcohol is present)
- •Those who avoid silicones (contains dimethicone)
- •People seeking a lightweight gel moisturizer
- •Users looking for anti-aging actives like retinol or peptides
Key Ingredients
| Ingredient | Concentration | Function |
|---|---|---|
| Sodium DNA (PDRN) | — | Cosmetic-grade polydeoxyribonucleotide. In clinical settings, PDRN injections promote tissue repair. In topical cosmetics, Sodium DNA is used for hydration and skin conditioning. Topical efficacy data is limited compared to injectable PDRN research. |
| Hyaluronic Acid Complex (8 types) | — | Eight molecular weight variants including sodium hyaluronate, hydrolyzed hyaluronic acid, hydroxypropyltrimonium hyaluronate, potassium hyaluronate, sodium acetylated hyaluronate, hydrolyzed sodium hyaluronate, sodium hyaluronate crosspolymer, and hyaluronic acid. Different sizes penetrate to different skin depths. |
| Ceramide NP | — | Skin-identical lipid that helps restore and maintain the barrier. Works with squalane to reinforce the lipid matrix. |
| Squalane | — | Lightweight emollient derived from plant sources. Mimics skin's natural sebum. Provides moisture without a heavy or greasy feel. |
The Formulation Explained
PDRN in topical skincare
PDRN (polydeoxyribonucleotide) gained popularity from injectable treatments used in dermatology for wound healing and skin rejuvenation. In topical cosmetics, Sodium DNA is the ingredient used. Research on topical PDRN is more limited than injectable data. The ingredient may provide hydration and conditioning benefits, but claims about tissue repair should be understood in the context of topical delivery limitations.
Eight hyaluronic acid variants
The formula includes eight distinct forms of hyaluronic acid with different molecular weights. Smaller variants like hydrolyzed hyaluronic acid can penetrate deeper into skin. Larger forms like sodium hyaluronate crosspolymer create a hydrating film on the surface. This multi-weight approach aims to hydrate at multiple skin levels simultaneously.
Barrier repair support
Ceramide NP, squalane, and panthenol form the barrier support system. These work alongside the hydrating actives to help prevent moisture loss. Allantoin and beta-glucan add soothing properties. The combination positions this as more than a simple hydrating cream.
What is not in here
The formula excludes fragrance, essential oils, parabens, and sulfates. It does contain dimethicone in small amounts. No retinoids, AHAs, BHAs, or other active treatments are included, keeping the focus on hydration and repair.
Ingredients to Know
Fatty alcohol emulsifier. Listed fourth, indicating a meaningful presence. Generally well tolerated but may trigger reactions in fatty alcohol-sensitive individuals.
Silicone occlusive. Listed near the end, suggesting a small amount for texture and moisture sealing.
Solvent and penetration enhancer. Helps other actives absorb into the skin. Listed fifth.
Vitamin E antioxidant. Present in small amounts for formula stability and mild antioxidant benefit.
User Feedback Patterns
Full INCI List
39 ingredients · Click "Show full list" to view
About Anua
Full INCI lists are provided. The brand does not disclose specific concentrations for Sodium DNA or individual hyaluronic acid types. Vegan status is confirmed by the brand.
Compare with Similar Products
Related Comparisons
More in Moisturizers
All comparisons featuring Anua PDRN Hyaluronic Acid 100 Cream
Side-by-side ingredient comparisons against every other product in our catalog.
- vs COSRX The Niacinamide 15 Serum
- vs Glow Recipe Watermelon Glow Niacinamide Dew Drops
- vs Good Molecules Niacinamide Brightening Toner
- vs La Roche Posay Mela B3 Serum
- vs Naturium Niacinamide Serum 12% Plus Zinc 2%
- vs Paula's Choice 10% Niacinamide Booster
- vs Paula's Choice Clinical Niacinamide 20% Treatment
- vs Peach & Lily Glass Skin Refining Serum
- vs Sunday Riley B3 Nice 10% Niacinamide Serum
- vs The Inkey List Niacinamide Oil Control Serum
- vs The Inkey List SuperSolutions 20% Niacinamide Serum
- vs The Ordinary Niacinamide 10% + Zinc 1% Serum
- vs Versed Just Breathe Clarifying Serum
- vs CeraVe PM Facial Moisturizing Lotion
- vs Dr. Althea 345 Relief Cream
- vs EQQUALBERRY NAD+ Peptide Boosting Cream
- vs EQQUALBERRY Vitamin Illuminating Cream
- vs L'Oreal Paris Collagen Moisture Filler Day/Night Cream
- vs La Roche-Posay Toleriane Double Repair Face Moisturizer
- vs La Roche-Posay Cicaplast Baume B5+
- vs Medicube PDRN Pink Collagen Capsule Cream
- vs Medicube Deep Vita C Capsule Cream
- vs Stratia Lipid Gold
- vs Bliss Bright Idea Vitamin C + Tri-Peptide Face Serum
- vs Drunk Elephant C-Firma Fresh Day Serum
- vs Eight Saints Seeking C Vitamin C Face Serum
- vs EQQUALBERRY Vitamin Illuminating Serum
- vs La Roche-Posay 10% Pure Vitamin C Anti-Aging Face Serum
- vs Maelove The Glow Maker
- vs Melano CC Intensive Anti-Spot Essence
- vs Paula's Choice C15 Super Booster
- vs SkinCeuticals C E Ferulic with 15% L-Ascorbic Acid
- vs Sunday Riley C.E.O. 15% Vitamin C Brightening Serum
- vs The Ordinary Ascorbyl Glucoside Solution 12%
- vs The Ordinary Vitamin C Suspension 23% + HA Spheres 2%
- vs Timeless 20% Vitamin C + E Ferulic Acid Serum
- vs TruSkin Vitamin C Serum for Face
- vs Vibriance Super C Serum
Sources
- • https://anua.us
- • https://incidecoder.com/products/anua-pdrn-hyaluronic-acid-100-cream
- • https://www.amazon.com/ANUA-Hyaluronic-Moisturizer-Hydrating-Sensitive/dp/B0DHPZ3NB2
- • https://global.oliveyoung.com/product/detail?prdtNo=GA240800135
- • https://skinsort.com/products/anua/pdrn-hyaluronic-acid-100-cream
Last updated: 2026-03
Rating Scales
Comedogenicity (0-5)
Likelihood of clogging pores. 0 = won't clog, 1-2 = low, 3 = moderate, 4-5 = high.
Irritancy (0-5)
Potential for skin irritation. 0 = non-irritating, 1-2 = low, 3 = moderate, 4-5 = high.
Ratings based on published ingredient studies. Individual reactions may vary.