Medicube PDRN Pink Peptide Serum
Links may contain affiliate codes.
Formulation Summary
A pink-tinted peptide serum featuring Rose PDRN (salmon DNA) and a five-type peptide complex. Niacinamide at an estimated 4.4-5.4% provides brightening support. The formula won the 2024 Glow Pick Award in Korea. It layers hydrolyzed collagen, atelocollagen, and sodium hyaluronate for hydration.
Medicube positions this as a dermatology-inspired anti-aging serum. The five peptide types each target different aging mechanisms: Copper Tripeptide-1 for collagen remodeling, Acetyl Hexapeptide-8 for expression lines, and Palmitoyl peptides for firmness signaling. Sodium DNA provides the PDRN component. Niacinamide appears second in the INCI list, indicating a significant concentration. The formula does contain fragrance, which is a departure from fragrance-free trends in K-beauty.
Quick Facts
Designed For
- •Those seeking peptide-based anti-aging with PDRN
- •Users who want a lightweight serum for morning and evening use
- •People interested in K-beauty award-winning products
- •Those looking for brightening alongside anti-aging benefits
- •Users who enjoy a subtle scented serum experience
May Not Suit
- •Vegans (contains salmon-derived and collagen ingredients)
- •Fragrance-sensitive individuals
- •Those prone to breakouts from isopropyl myristate (comedogenicity rating 3)
- •Users who prefer fragrance-free formulations
Key Ingredients
| Ingredient | Concentration | Function |
|---|---|---|
| Sodium DNA (Rose PDRN) | — | Polydeoxyribonucleotide from salmon DNA. Aims to support skin regeneration at the cellular level. Injectable PDRN has clinical support; topical evidence is still building. |
| Niacinamide | 4.4-5.4%third-party estimate | Listed second in INCI. Estimated by third-party analysis at 4.4-5.4%. Provides brightening, barrier support, and oil regulation. |
| Copper Tripeptide-1 | — | Signal peptide that promotes collagen and glycosaminoglycan production. Extensively researched for wound healing and skin remodeling. |
| Acetyl Hexapeptide-8 | — | Targets expression lines by modulating neurotransmitter release at the neuromuscular junction. Effect is mild compared to injectable alternatives. |
The Formulation Explained
Five-peptide approach
The formula uses five distinct peptide types, each with a different mechanism. Copper Tripeptide-1 and the three palmitoyl peptides target different aspects of collagen production and skin firmness. Acetyl Hexapeptide-8 specifically addresses expression lines. This breadth of peptides suggests Medicube is aiming for multi-target anti-aging rather than a single-mechanism approach.
PDRN from clinical to topical
PDRN injections are a mainstream treatment in Korean dermatology clinics. Medicube translates this into a topical product. The key question is penetration. Sodium DNA is a large molecule. The gel vehicle and penetration enhancers like isopropyl myristate may help, but topical efficacy data is limited compared to injectable.
2024 Glow Pick Award winner
This serum won the 2024 Glow Pick Award in Korea, reflecting strong consumer reception in its home market. Glow Pick is a major Korean beauty review platform where products are rated by real users.
Ingredients to Know
Emollient with a comedogenicity rating of 3. May trigger breakouts in acne-prone individuals. Used to enhance penetration of other actives.
Antioxidant that supports cellular energy. Generally well tolerated. Present in small amounts based on INCI position.
Undisclosed fragrance blend. Can be an irritant for sensitive skin. Positioned mid-list in the INCI.
User Feedback Patterns
Full INCI List
39 ingredients · Click "Show full list" to view
About Medicube
Does not disclose exact active concentrations. Third-party analysis estimates niacinamide at 4.4-5.4%. INCI lists available on packaging.
Compare with Similar Products
Related Comparisons
More in Serums
All comparisons featuring Medicube PDRN Pink Peptide Serum
Side-by-side ingredient comparisons against every other product in our catalog.
- vs COSRX The Niacinamide 15 Serum
- vs Glow Recipe Watermelon Glow Niacinamide Dew Drops
- vs Good Molecules Niacinamide Brightening Toner
- vs La Roche Posay Mela B3 Serum
- vs Naturium Niacinamide Serum 12% Plus Zinc 2%
- vs Paula's Choice 10% Niacinamide Booster
- vs Paula's Choice Clinical Niacinamide 20% Treatment
- vs Peach & Lily Glass Skin Refining Serum
- vs Sunday Riley B3 Nice 10% Niacinamide Serum
- vs The Inkey List Niacinamide Oil Control Serum
- vs The Inkey List SuperSolutions 20% Niacinamide Serum
- vs The Ordinary Niacinamide 10% + Zinc 1% Serum
- vs Versed Just Breathe Clarifying Serum
- vs Anua PDRN Hyaluronic Acid 100 Cream
- vs CeraVe PM Facial Moisturizing Lotion
- vs Dr. Althea 345 Relief Cream
- vs EQQUALBERRY NAD+ Peptide Boosting Cream
- vs EQQUALBERRY Vitamin Illuminating Cream
- vs L'Oreal Paris Collagen Moisture Filler Day/Night Cream
- vs La Roche-Posay Toleriane Double Repair Face Moisturizer
- vs La Roche-Posay Cicaplast Baume B5+
- vs Medicube PDRN Pink Collagen Capsule Cream
- vs Medicube Deep Vita C Capsule Cream
- vs Stratia Lipid Gold
- vs Bliss Bright Idea Vitamin C + Tri-Peptide Face Serum
- vs Drunk Elephant C-Firma Fresh Day Serum
- vs Eight Saints Seeking C Vitamin C Face Serum
- vs EQQUALBERRY Vitamin Illuminating Serum
- vs La Roche-Posay 10% Pure Vitamin C Anti-Aging Face Serum
- vs Maelove The Glow Maker
- vs Melano CC Intensive Anti-Spot Essence
- vs Paula's Choice C15 Super Booster
- vs SkinCeuticals C E Ferulic with 15% L-Ascorbic Acid
- vs Sunday Riley C.E.O. 15% Vitamin C Brightening Serum
- vs The Ordinary Ascorbyl Glucoside Solution 12%
- vs The Ordinary Vitamin C Suspension 23% + HA Spheres 2%
- vs Timeless 20% Vitamin C + E Ferulic Acid Serum
- vs TruSkin Vitamin C Serum for Face
- vs Vibriance Super C Serum
Sources
- • https://medicube.us/products/rose-pdrn-pink-peptide-serum
- • https://incidecoder.com/products/medicube-pdrn-pink-peptide-serum
- • https://skinsort.com/products/medicube/pdrn-pink-peptide-serum
- • https://www.amazon.com/medicube-Niacinamide-Hydrating-Moisturizing-Skincare/dp/B0DCJ7952P
- • https://www.ulta.com/p/pdrn-pink-peptide-serum-pimprod2053536
- • https://whatsinmyjar.com/product/medicube-pdrn-pink-peptide-serum
- • https://britishbeautyblogger.com/article/medicube-pdrn-pink-peptide-serum-review/
Last updated: 2026-03
Rating Scales
Comedogenicity (0-5)
Likelihood of clogging pores. 0 = won't clog, 1-2 = low, 3 = moderate, 4-5 = high.
Irritancy (0-5)
Potential for skin irritation. 0 = non-irritating, 1-2 = low, 3 = moderate, 4-5 = high.
Ratings based on published ingredient studies. Individual reactions may vary.